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Most sufferers (82%) have required some degree of supplemental oxygen during hospital admission. Maximal degree of respiratory support has included high-flow nasal cannula assist (47%), non-invasive constructive strain air flow (30%), and invasive mechanical air flow (22%) [63, 70, 72]. Severe instances of EVALI have required veno-venous extracorporeal membrane oxygenation (VV-ECMO) with one case proceeding to lung transplantation [56, 71, 74].
